On 6 september 2016 the vectorborne diseases vbd team of who myanmar convened a technical workshop to develop the national clinical management guidelines for dengue and dengue hemorrhagic fever dhf, in support of myanmar health authorities and with the collaboration of experts and academics from the universities of medicines of the country. Dengue hemorrhagic fever and dengue shock syndrome some patients with dengue fever go on to develop dengue hemorrhagic fever dhf, a severe and sometimes fatal form of the disease. Clinical study of diagnosed cases of dengue fever in tertiary care. Most dengue virus infections are asymptomatic, but some patients may develop either dengue fever or the more severe dengue hemorrhagic fever. Kalayanarooj s, vaughn dw, nimmannitya s, green s, suntayakorn s, kunentrasai n, viramitrachai w, ratanachueke s. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever vii dengue fever is the fastest emerging arboviral infection spread by aedes mosquitoes with major public health consequences in over 100 tropical and subtropical countries in southeast asia, the western pacific and south and central america.
Dengue fever df is the most prevalent mosquitoborne viral illness in the world endemic in more than 100 countries, with 2. Clinical and serologic study of cuban children with dengue hemorrhagic feverdengue shock syndrome dhfdss. Pdf we report a case of imported dengue hemorrhagic fever dhf in a 10year old philippine boy. These viruses are related to the viruses that cause the west nile infection and yellow fever. Dengue hemorrhagic fever is a fatal manifestation of dengue virus that manifest with bleeding diathesis and hypovolemic shock. Dengue fever and dengue hemorrhagic fever are reemerging diseases that are endemic in the tropics. Diagnosis of dengue infection during pregnancy surely affects management options and decisions as the mode and time of delivery are of utmost importance. Clinical manifestations and management of denguedhfdss ncbi. Dengue is a potentially fatal acute febrile illness caused by infection with any of four dengue viruses denv1, 2, 3, and 4. As both cell tropism and tissue tropism of denv are considered major determinants in the pathogenesis of dengue, there is a critical need for adequate tropism. Dengue fever is a mosquitoborne viral illness found throughout the.
The incubation period from infection to onset of symptoms is three days to two weeks. The early prediction of severe dengue in patients without any warning signs who may later develop severe dhf is very important to choose. These symptoms could indicate a progression to dengue hemorrhagic fever, the severest form of the disease, with fatality rates as high as 20 percent. Dengue is a mosquitoborne disease caused by any one of four closely related dengue. Dengue is caused by four different strains of virus. In contrast, most infections among children under age 15 years are asymptomatic or minimally symptomatic. Treatment includes rehydration and recovery is expected.
Dengue fever is common in tropical areas, so take extra precautions if you travel somewhere with this type of climate. Duane j gubler, dukenus graduate medical school, singapore, eng eong ooi, dukenus graduate medical school, singapore, goro kuno, arboviral disease branch, centers for disease control and prevention, subhash vasudevan, dukenus graduate medical school, singapore, jeremy farrar, wellcome trust, uk. Aug 25, 2019 dengue fever, or west nile fever, is a mild viral illness transmitted by mosquitoes which causes fever, rashes and muscle and joint aches. After fever reduces, patient develops severe vomiting and abdominal pain with breathing difficulty. Why only some people develop lifethreatening dengue infections. Dengue hemorrhagic fever nursing care management and study guide.
Infection with one of these serotypes does not provide crossprotective immunity, so persons living in a dengueendemic area can have four dengue infections during their lifetimes. The causative agent of denfue hemorrhagic fever dhf is dengue virus, of which there are 4 serotypes. Dengue hemorrhagic fever dhf dhf is a severe form of dengue infection. Pdf we report a case of imported dengue hemorrhagic fever dhf in a 10yearold philippine boy. The global prevalence of dengue cases has increased in southeast asia. Management of dengue fever dengue hemorrhagic fever. Aug 17, 2011 management of dengue fever and dengue hemorrhagic fever slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
We propose a new hypothesis for the immunopathogenesis for dengue virus. We described the highresolution ct findings in a 70yearold male with the disease, which was diagnosed by clinical examination and confirmed by serological methods. Dengue fever is one of the most common tropical diseases worldwide. Four related types of dengue viruses denv1, 2, 3 and 4 can cause dengue fever in majority of cases, the mosquito named aedes aegypti is responsible in the spread of the disease. Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity the cocirculation of multiple serotypes, and the emergence of dengue hemorrhagic fever in new geographic regions. Known also as dengue hemorrhagic fever dhf, it starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat. A second exposure to the virus can result in dengue hemorrhagic fever, a lifethreatening illness. Management of dengue fever and dengue hemorrhagic fever slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. To provide a national incidence rate and case fatality rate of dengue hemorrhagic fever in indonesia through an analysis of the national disease surveillance database from the directorate general of disease prevention and control of ministry of health. Most adults were positive for symptoms like fever, myalgia, arthralgia, and skin rash and bleeding. Highresolution ct demonstrated bilateral areas of consolidation with air bronchogram and ground glass opacities, as well as small bilateral. There is a need for laboratory confirmation if technology exists. The viruses that cause dengue fever are related to those that.
Pdf risk factors for hemorrhage in severe dengue infections. Dec 07, 2018 dengue is also known as breakbone fever, hemorrhagic fever, dandy fever, infectious thrombocytopenic purpura. Dengue and dengue hemorrhagic fever linkedin slideshare. The aedes aegypti mosquito is mostly found in tropical areas including subcontinent, pakistan, africa and latin. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis. Dengue fever, or west nile fever, is a mild viral illness transmitted by mosquitoes which causes fever, rashes and muscle and joint aches. Transmission almost all transmission occurs through the bite of infected aedes mosquitoes, primarily aedes aegypti and ae. There are several mosquitoes in the tropic areas that are carriers of the dengue virus and this mosquito can also be infected if it bites any person who has dengue virus in his blood. In their case report about a tourist with dengue fever and visual loss, christos haritoglou and colleagues oct 5, p 10701 state that there are four stages of dengue fever. Dengue feverdengue hemorrhagic fever dengue feverdengue hemorrhagic fever bruce r. Dss3,4caused by infection with dengue virus, is not a new disease, but.
The who deems it not appropriate to adopt a detailed clinical definition of dengue fever because of the variability in the clinical illness associated with dengue infection. Dengue hemorrhagic fever may arise from repeated infection with different serotypes of the dengue virus. Todays topics arboviruses general concept dengue fever and dengue hemorrhagic fever mcqs and case studies 3. Infection with one of these serotypes does not provide crossprotective immunity, so persons living in a dengue endemic area can have four dengue infections. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever iv.
More severe forms of the disease, dengue hemorrhagic fever or dengue shock syndrome are very rare among travelers. Dengue is a mosquitoborne seasonal viral infection, caused by four closely related viruses denv 14. When a person is infected with dengue virus for the first time, clinical signs and symptoms are usually mild. If you continue browsing the site, you agree to the use of cookies on this website. Disease burden of dengue fever and dengue haemorrhagic fever 3. Around the time the fever begins to subside usually 37 days after symptom onset, the patient may develop warning signs of severe disease.
Dengue fever does not need to be fatal, if the patient is able to access proper medical care, or is able to source good homebased preventive care. Transmission almost all transmission occurs through the bite of infected aedes mosquitoes, primarily. Dengue, an acute febrile illness, is caused by infection with any of 4 related positivesense, singlestranded rna viruses of the genus flavivirus, dengue viruses 1, 2, 3, or 4. Management of severe dengue hemorrhagic fever and bleeding. Other members of the same genus include yellow fever virus, west nile virus, zika virus, st. Dengue and dengue hemorrhagic fever dhf are caused by one of four closely related, but antigenically distinct, virus serotypes den1, den2, den3, and den4, of the genus flavivirus. Dengue fever is also known as backbone fever and the virus cannot be directly transmitted from one person to another. Dengue fever and dengue haemorrhagic fever the lancet. The increasingly widespread distribution and the rising incidence of dengue virus infections are related to increased. Dengue is a major public health problem worldwide, where an estimated 400 million denv infections and 100 million clinically apparent dengue cases occurred in 2010. A syndrome due to the dengue virus that tends to affect children under 10, causing abdominal pain, hemorrhage bleeding and circulatory collapse. Gubler d engue and dengue hemorrhagic fever dhf are caused by infection with dengue viruses. In this case report, we will discuss the pathophysiology and management of severe dengue hemorrhagic fever and bleeding complications in an intensive care unit icu.
Dengue fever is a disease spread by the aedes aegypti mosquito and caused by one of four dengue viruses that are closely related. How to cure dengue fever the solution and best home. Epidemiology of dengue hemorrhagic fever in indonesia. Finally, dengue diagnosis is of major importance for research into host, virus and vector characteristics. Department of health and human services centers for. Fatality is a distinct possibility only if the fever graduates to a more serious condition called the dengue hemorrhagic fever dhf. Who is at greater risk for developing dengue hemorrhagic fever. Dengue is commonly confused with other infectious illnesses such as influenza, measles, malaria, typhoid, and scarlet fever. Dengue hemorrhagic fever can occur when someone is bitten by a mosquito or exposed to blood infected with the dengue virus. Dengue virus infection causes dengue fever df, dengue hemorrhagic fever. Dengue fever virus denv is an rna virus of the family flaviviridae.
Developing guidelines for the clinical management of. Dengue fever is a virus transmitted to humans through bites from the aedes mosquito, a daybiting mosquito. Viral hemorrhagic fever dengue fever presented by jega subramaniam, student guided by ap. Yoshiki kusama at national center for global health and medicine hospital. To view the erratum, please click here dengue fever is a mosquitotransmitted disease caused by any of four closely related virus serotypes den1, den2, den3, and den4 of the genus flavivirus. Dhf starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat, cough, nausea, vomiting, and abdominal pain. Dengue fever is a selflimited acute illness that lasts for 2 to 7 days and includes fever, rash, myalgia, and arthralgia. Pulmonary hemorrhage syndrome associated with dengue fever.
Dengue diagnosis, advances and challenges sciencedirect. Jun 28, 2019 people with weakened immune systems as well as those with a second or subsequent dengue infection are believed to be at greater risk for developing dengue hemorrhagic fever. Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever df, or severe forms, such as dengue hemorrhagic fever dhf and dengue shock syndrome dss in affected individuals. Dengue fever is caused by virus that is transmitted when a specific type of mosquito bites humans. An outbreak took place in the philippines and thailand but is now more prominent in the countries of asia and latin america, where it is one of the main contributors to hospitalization and death. Guidelines for dengue hemorrhagic fever case management. Immunopathogenesis of dengue virus infection springerlink. Opinion 10 days of dengue fever the new york times. Guerdan, md, mph abstract in september 2009 the first documented, locally acquired cases of dengue fever in eighty years were diagnosed in individuals living in or visiting key west, florida. It is a vasculopathy that consists in endothelial lesions which allow plasma leakage and hemorrhages. In the first four days after onset of fever, either rtpcr or virus isolation are the recommended assays for confirmation of dengue infection 30. The symptoms of typical dengue fever are controllable and manageable.
Technical guides for diagnosis, treatment, surveillance, prevention and control of dengue haemorrhagic fever. Louis encephalitis virus, japanese encephalitis virus, tickborne encephalitis virus, kyasanur forest disease virus, and omsk hemorrhagic fever virus. Jan 17, 2016 dengue and dengue hemorrhagic fever 1. Denv serotypes can be further classified into different. To view the erratum, please click here dengue fever is a mosquitotransmitted disease caused by any of four closely related virus serotypes den1. Description of the clinical picture of dengue hemorrhagic feverdengue shock syndrome dhfdss in adults. However, disease caused by dengue virus infection is classified into two clinical entities. When a person is infected with dengue virus for the first. Graham in 1903 implicated aedes aegypti as the vector for the disease and the virus was isolated in 1944 by albert sabin et al1. A risk factor for dengue hemorrhagic fever request pdf. Otherwise it has proposed the following classification. It gets transmitted by the bite of the female mosquito of genus aedes. Dengue chapter 4 2020 yellow book travelers health cdc.
Esse video devidamente registrado, esta a venda juntamen. The purpose of this study is to describe the care provided in a hydration tent, including early detection, treatment, and serial followup. According to the virus virulence hypothesis, certain denv strains are responsible for more severe disease. Pdf a pediatric case of imported dengue hemorrhagic fever in japan. The illness may last up to 10 days, but complete recovery can take 2 to 4 weeks. A second exposure to the virus can result in dengue hemorrhagic fever, a. Severe dengue is called dengue hemorrhagic fever dhf and dates back to the 1950s. Fever that lasts from 2 to 7 days with general signs and symptoms of nausea, vomiting, abdominal pain and headache, followed by hemorrhagic. Typical clinical manifestations of dengue range from selflimited dengue fever df to dengue hemorrhagic fever with shock syndrome. Dengue fever dengue hemorrhagic fever dengue fever dengue hemorrhagic fever bruce r. The global prevalence of dengue cases has increased in southeast asia, africa, the western pacific, and the americas. These viruses are related closely to each other antigenically, and, as. Available data has indicated an increasing trend of dengue hemorrhagic fever incidence in indonesia over the past 50 years.
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